QCM-D Quartz Crystal Microbalance

 

with Dissipation Monitoring

 

Q-Sense instruments - tracking changes at the surface - are based on the patented QCM-D technique. The instruments measure in real-time the mass of molecular layers that form on the quartz sensor. Simultaneously structural (viscoelastic) properties of such molecular layers are monitored, which enables distinction between two similar interactions or observation of a phase transition in bound layers. Measurements of both mass and structural properties gives a thorough understanding of binding events such as molecular adsorption and interaction. Moreover, the QCM-D technique makes it possible to extract water content of molecular layers, in contrast to optical mass measurements, and allows several kinds of substrates such as metals, polymers and functionalised coatings for controlled studies of interactions.

 

This enables the extraction of various informations about e.g. Kinetics, Affinity, Specifity, Structure, Mass, Film thickness

 

Q-Sense offers complete turnkey systems that include everything that is needed to quickly get started and produce high quality data. The instrument will be installed in your laboratory and the users will be educated in order to gain the full potential of QCM-D.

 

 

 

 

Detailed Information

 

Einführung in die QCM-D Technik

 

Brochures

 

Quartz Crystal Microbalance with Dissipation (QCM-D)

Q-Sense Modules Product Specifications

Consumables

 

Application examples

 

Cells and Molecular Biology

Early detection of biofilm formation on steel surfaces

Simultanous QCM-D and microscopy monitoring of cell Adhesion with the q-sense window module

 

Lipids

Combined QCM-D Ellipsometry setup for real time

Enzymatic degradation of lipid films caused by lipase

Functionalised lipid bilayer for specific protein interaction studies

Lipid bilayer formation; a comparison between QCM-D SPR and AFM

Specificity of DNA hybridisation on a functionalised lipid bilayer

 

Polymers

Monitoring of polyelectrolyte multilayer build up and cross-linking using QCM-D

Real time thickness monitoring of polyelectrolyte multilayer formation in situ

Nucleation of calcium phosphate crystals on polyelectrolyte multilayers

Swelling kinetics of a cellulose model film

 

Proteins

QCM-D as a powerful real-time screening tool for protein adsorption onto glass and plastic surfaces

Analyzing enzymatic activity on functionalized surfaces

Combined QCM-D Ellipsometry setup for real time

Enzymatic degradation of lipid films caused by lipase

Functionalised lipid bilayer for specific protein interaction studies

Hemocompatibility of Hydroxyapatite

Probing repeated antibody-antigen interactions by the use of Q-Sense biotin functionalized sensors

Protein fibrillation studied with QCM-D

QCM-D study of molecular conformational effects on protein - DNA interactions

Specificity of DNA hybridisation on a functionalised lipid bilayer

Structural change of adsorbed protein layer

Viscosity measurements with QCM-D

 

Surfactants and cleaning

Analyzing cleaning and degradation Processes

Analyzing enzymatic activity on functionalized surfaces

Low molecular weight surfactant adsorption to a gold surface

Analysing vapor uptake & release with QCM-D

Protein adsorption as biocompatibility evaluation method for implant surfaces